Vitamin D Filomena Vieira

Skin cancer prevention with vitamin D

With the summer come the skin cancer warnings. 
The journal "Dermato-Endocrinology", January, 2013, published an article which we found very promising for prolonged sun bathing lovers.

This scientific study highlights the photo capacity protection of vitamin D (VD), in its most active form, 1,25 -dihidroxivitamin D3, as well as their derivatives, lumisterol, and compounds similar to VD as bufalin.

According to the authors the VD components can potentially prevent skin cancer when used in dermatological products. This study is focused on the protective action of VD and its components.

The explanation is as follows:
The same radiation that produces VD, also causes changes in skin cellular DNA whose final result can be skin cancer.

The benefits of VD produced by the sun are indisputable: in the prevention of rickets, the reduction of falls, fractures, mortality and depression, allergy and autoimmunity.

Due to the high incidence of skin cancer it is vital to find a balance between solar radiation to produce enough VD and prevent the harmful effects of UV radiation, cancer and photo aging.

Technically the active form of VD, 1,25(OH)2D3 is a steroid hormone synthesized by the skin after the photochemical conversion of 7-dehydrocholesterol from the epidermis. The energy required for the chemical reaction, is provided by UV solar radiation.
From the continued sun exposure results the formation of vitamin D metabolites: lumisterol, taquisterol and supraesterol.

Carcinogenesis is a multiple process that requires initiation, promotion and progression. UV radiation is responsible for 90% of skin cancer: melanoma and non-melanoma. The photo protective effect of 1,25 (OH) 2D3 is related to the increase the survival of skin cells after prolonged sun exposure, reducing the destruction of DNA and cell apoptosis.

VD analogs are being studied for its application with creams, after sun bathing, as is the case of lumisterol. The bufalin is extracted from venom of a species of frog (Bufo) which is a steroid having the same properties as VD (photo protection, activation of VD Receptor and reduction of the destruction of the DNA by UV radiation) is being studied for use in humans.
Applying VD or similar products, during and immediately after sun exposure, can help to increase the protection of the skin against photo carcinogenesis.

For more information, we recommend this and this text. 

BluEmerald, for a healthy, conscious and sustainable life!


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